An Independent Review of Hoodia Studies

The Hoodia studies conducted by Phytopharm in collaboration with The Council for Scientific and Industrial Research (CSIR) have assessed the role of the Hoodia Gordonii plant as a natural appetite suppressant. The plant is considered to play a crucial role in the fight with obesity by lowering the appetite and the craving for sweets.

The Study Performed by Phytopharm
The study conducted by Phytopharm has the role to determine the effects of the concentrated spray dried extract of Hoodia, known as PYM50027, in healthy male subjects.

The results have suggested that, besides its role as a natural appetite suppressant, PYM50027 is interfering in the bilirubin metabolism. This means that it causes hyperbilirubinaemia, but it does not have any other effects on bile salt secretion.

The side effects from the 15 day repeat dose study are: taste perversion, paraesthesia and the above mentioned hyperbilirubinaemia.

The study’s main conclusion is that the PYM50027 is an effective natural appetite suppressant but further testing is required. Moreover, the dosing regimen of 1800 mg is considered too high for future treatments.

Conclusions and Recommendations of the Independent Review
The role of PYM50027 as an inhibitor of the bilirubin metabolism at several levels cannot be excluded by the data from the Hoodia study. Its role for the inhibition of glucoronidation, hepatic uptake and other canalicular transporters should also be investigated.

The independent review of the study made the following recommendations for further investigations of the mechanism of increased bilirubin due to the PYM50027 dosage:

– Unconjugated bilirubin will accumulate in the plasma if there is a marked increase in the rate of formation of bilirubin
– Unconjugated bilirubin will accumulate in the plasma if there is a defect in any of the processes underlying the hepatic clearance of the unconjugated pigment
– Impaired hepatic clearance of conjugated bilirubin will cause efflux or conjugated bilirubin in the plasma

However, the 15 day repeat dose study of the Hoodia Gordonii is an exploratory study to determine the role of the plant extract as a natural appetite suppressant. The treatment has had good results in lowering the healthy male subjects’ calorie intake. This suggests that further studies are necessary to be conducted on the PYM50027 at a dosing regimen lower than 1800 mg or on associated products.

The advantages of the Hoodia Gordonii extract are:
– It reduces your appetite for sweets
– It gives you a feeling of satiety by tricking the brain in believing that you have already eaten
– You have a reduced interest for food
– You will have excellent health

All the above-mentioned advantages make the Hoodia Gordonii the most popular natural appetite suppressant.